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Azaleatin

SKU: orb1297454

Description

Azaleatin, a natural flavonoid isolated from Rhododendron simsii, acts as a dipeptidyl peptidase-IV (DPP-IV) inhibitor. This mechanism supports its application in metabolic research, particularly for studying type 2 diabetes and obesity in both in vitro and in vivo experimental models.

Research Area

Protein Biochemistry

Images & Validation

Key Properties

CAS Number529-51-1
MW316.26
Purity99.05% (May vary between batches)
FormulaC16H12O7
SMILESCOc1cc(O)cc2oc(-c3ccc(O)c(O)c3)c(O)c(=O)c12
TargetProteasome,DPP-4
SolubilityDMSO:55 mg/mL (173.91 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.16 mM)

Bioactivity

In Vitro
A survey of leaf hydrolysates of 52 species in section Vireya of Rhododendron showed that the flavonols kaempferol, quercetin and myricetin were commonly present. However, other more characteristic Rhododendron flavonol derivatives were either rare (caryatin, Azaleatin) or absent (gossypetin). A study of the glycosides in four representative species showed that quercetin and kaempferol were present as the 3-rhamnoside, 3-glucoside, 3-galactoside or 3-rutinoside.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Rhododendron, peptidase-IV, type-2, flavonol, inhibit, Inhibitor, obesity, O-methylated, Dipeptidyl Peptidase, dipeptidyl, DPP-4, DPP4, DPP, diabetes, Azaleatin

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Key Properties

No computed properties available.

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Protocol Information

Azaleatin (orb1297454)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 150.00
2 mg
$ 190.00
5 mg
$ 300.00
1 ml x 10 mM (in DMSO)
$ 310.00
10 mg
$ 430.00
25 mg
$ 690.00
50 mg
$ 930.00
100 mg
$ 1,230.00
200 mg
$ 1,670.00
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