Cart summary

You have no items in your shopping cart.

AZD7624

SKU: orb1308607

Description

AZD7624

Research Area

Cell Biology, Signal Transduction

Images & Validation

Key Properties

CAS Number1095004-78-6
MW491.56
Purity99.37%
FormulaC27H30FN5O3
SMILESCNCCOc1ccccc1C1(CC1)Nc1nccn(-c2cc(cc(F)c2C)C(=O)NC2CC2)c1=O
Targetp38 MAPK,Autophagy,TNF
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.07 mM);DMSO:50 mg/mL (101.72 mM)

Bioactivity

Target IC50
TNF-α:8.4(human mononuclear cells), 8.1(whole blood), 9.0 (alveolar macrophages)
In Vitro
AZD7624 effectively suppresses LPS-induced TNFα production in human mononuclear cells, whole blood, and alveolar macrophages in vitro, exhibiting potent anti-inflammatory activity. This inhaled p38 inhibitor demonstrates significant efficacy with pIC50 values of 8.4, 8.1, and 9.0, respectively, highlighting its potential therapeutic application.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

AZD7624, AZD-7624, AZD 7624, Autophagy, Inhibitor, p38MAPK, p38, p38 MAPK, inhibit, TNF-α
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

AZD7624 (orb1308607)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 110.00
5 mg
$ 210.00
1 ml x 10 mM (in DMSO)
$ 220.00
10 mg
$ 310.00
25 mg
$ 540.00
50 mg
$ 800.00
100 mg
$ 1,120.00
DispatchUsually dispatched within 3-5 working days
Bulk Enquiry