Azelastine hydrochloride

SKU: orb1223994

Description

Azelastine HCl is a potent, second-generation, selective, histamine antagonist.(In Vitro):Azelastine hydrochloride can significantly inhibit HNEpC proliferation, and therefore, be helpful in against airway remodeling.(In Vivo):Azelastine hydrochloride (4 mg/kg; p.o.; daily; for 8 weeks) significantly reduces blood glucose, HbA1c and serum alkaline phosphatase (ALP), osteocalcin and downregulates apolipoprotein B in diabetic hyperlipidemic rats model.Azelastine hydrochloride (4 mg/kg; p.o.; daily; for 8 weeks) improves the lipid profile (LDL-c decrease and HDL-c increase) in diabetic hyperlipidemic rats model.Azelastine hydrochloride (4 mg/kg; p.o.; daily; for 8 weeks) attenuates calcium deposition and aortic calcification in diabetic hyperlipidemic rats model.

Images & Validation

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Key Properties

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CAS Number	79307-93-0
MW	418.36
Purity	>98% (HPLC)
Formula	C₂₂H₂₄ClN₃O·HCl
SMILES	CN1CCCC(CC1)N2C(=O)C3=CC=CC=C3C(=N2)CC4=CC=C(C=C4)Cl.Cl
Target	Histamine Receptor
Solubility	Ethanol: 84 mg/mL (200.78 mM); Water: 35 mg/mL (83.66 mM); DMSO: 84 mg/mL (200.78 mM)

Bioactivity

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In Vivo

Azelastine hydrochloride (4 mg/kg; p.o. ; daily; for 8 weeks) significantly reduces blood glucose, HbA1c and serum alkaline phosphatase (ALP), osteocalcin and downregulates apolipoprotein B in diabetic hyperlipidemic rats model. Azelastine hydrochloride (4 mg/kg; p.o. ; daily; for 8 weeks) improves the lipid profile (LDL-c decrease and HDL-c increase) in diabetic hyperlipidemic rats model. Azelastine hydrochloride (4 mg/kg; p.o. ; daily; for 8 weeks) attenuates calcium deposition and aortic calcification in diabetic hyperlipidemic rats model. Animal model: Male albino Wistar rats (150-170 g), diabetic hyperlipidemic rats model. Dosage: 4 mg/kg. Administration: Oral administration, daily, for 8 weeks. Result: Ameliorated aortic calcification and increased apolipoprotein A expression along with a decline in apolipoprotein B.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Gene Symbol

Histamine Receptor

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