Queen's Award Received in 2021 ISO 9001 Certified Delivered over 1,000,000 bio-reagents to life science researchers Trusted by Life Science Communities
Cart summary

You have no items in your shopping cart.

BAL-0028

SKU: orb2308703

Description

BAL-0028 is a highly potent, nanomolar-range NLRP3 inflammasome inhibitor (IC50: 25 nM) with demonstrated anti-inflammatory effects. It is a valuable research tool for studying NLRP3-driven pathologies, including cancer, in both cellular assays and in vivo disease models.

Research Area

Immunology & Inflammation, Signal Transduction

Images & Validation

Key Properties

CAS Number2842012-69-3
MW403.45
Purity99.16%
FormulaC24H22FN3O2
SMILESO=C(C=1C=CC(=C(OCC)C1)C2=CC=CC(F)=C2)N(C)CC3=CC=CC=4C=NNC43
TargetInterleukin,NOD,NOD-like Receptor (NLR)

Bioactivity

Target IC50
NLRP3:25 nM
In Vitro
A series of novel high-affinity, reversible inhibitors of NLRP3 activation were discovered by screening a DNA-encoded library, and a potent lead compound, BAL-0028, was identified directly from the screen with an IC50 value of 25 nM; SPR studies showed that BAL-0028 binds tightly to the NACHT domain of NLRP3 (KD range of 104-123 nM); CADD analysis of the interaction of BAL-0028 with the NLRP3 NACHT domain showed that the binding site is distinct from that of ADP and MCC950 and includes site-specific interactions.

Storage & Handling

Storagekeep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

BAL0028, BAL 0028, NLRP3
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

BAL-0028 (orb2308703)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 80.00
1 ml x 10 mM (in DMSO)
$ 120.00
5 mg
$ 120.00
10 mg
$ 170.00
25 mg
$ 290.00
50 mg
$ 440.00
100 mg
$ 700.00
200 mg
$ 960.00
DispatchUsually dispatched within 5-10 working days
Bulk Enquiry