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Balsalazide

SKU: orb1221770

Description

Balsalazide is an anti-inflammatory agent for treatment of Inflammatory Bowel Disease.

Images & Validation

Key Properties

CAS Number80573-04-2
MW357.32
Purity>98% (HPLC)
FormulaC17H15N3O6
SMILESOC(=O)CCNC(=O)c1ccc(cc1)\N=N\c1ccc(O)c(c1)C(O)=O
TargetLipoxygenase
SolubilityDMSO : ≥ 41 mg/mL; 114.74 mM

Bioactivity

In Vivo
At the endpoint, the protein production of MIP-1β, MCP-1, IL-6, and IL-10 in the colon tissues decrease in concordance with the plasma concentrations of the cytokines. The drug-treated groups reveal lower expression of p-STAT3 compared to the CAC group. In addition, BCL2 decreases and BAX increases markedly in the BSZ+VSL#3 group. Balsalazide is a new 5-aminosalicylic acid (5-ASA) containing prodrug.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Balsalazide

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Balsalazide (orb1221770)

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