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Barbadin

SKU: orb1707595

Description

Barbadin is a specific inhibitor of β-arrestin/β2-adaptin interactions, blocking agonist-promoted endocytosis of GPCRs like the β2-adrenergic receptor. It has been used in research on obesity, demonstrating in vivo effects such as potentiating lorcaserin-induced weight loss in animal models.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number356568-70-2
MW333.407
Purity99.10% (May vary between batches)
FormulaC19H15N3OS
SMILESNN1C=NC2=C(C(=CS2)C2=CC=C(CC3=CC=CC=C3)C=C2)C1=O
TargetArrestin,Apoptosis
SolubilityDMSO:60 mg/mL (179.96 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6 mM)

Bioactivity

Target IC50
β-arrestin1:19.1 μM|β-arrestin2:15.6 μM

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Barbadin, β-arrestin2, β-arrestin, β-arrestin1

Similar Products

  • Barbadin [orb2901621]

    >98% (HPLC)

    356568-70-2

    333.41

    C19H15N3OS

    2 mg, 100 mg, 500 mg, 1 g
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

1 mg
$ 90.00
5 mg
$ 170.00
1 ml x 10 mM (in DMSO)
$ 190.00
10 mg
$ 240.00
25 mg
$ 370.00
50 mg
$ 530.00
DispatchUsually dispatched within 5-10 working days
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