BAY 11-7082

SKU: orb1307179

Description

BAY 11-7082 (also known as BAY 11-7821) is a cell-permeable small molecule that potently inhibits the deubiquitinases USP7 and USP21, and also suppresses NF-κB activation by blocking TNFα-induced IκBα phosphorylation. This dual activity makes it a valuable research tool for studying inflammatory signaling, immune regulation, and cancer pathways in both cellular and animal models.

Research Area

Cell Biology, Molecular Biology, Protein Biochemistry, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	19542-67-7
MW	207.25
Purity	99.92% (May vary between batches)
Formula	C₁₀H₉NO₂S
SMILES	Cc1ccc(cc1)S(=O)(=O)\C=C\C#N
Target	Autophagy,IκB/IKK,DUB,NF-κB,Apoptosis
Solubility	Ethanol:5.2 mg/mL (25.09 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2.08 mg/mL (10.04 mM);DMSO:29.6 mg/mL (142.82 mM)

Bioactivity

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Target IC50	IκBα phosphorylation:10 μM\|IκBα phosphorylation:10 μM\|USP21:0.96 μM\|USP7:0.19 μM
In Vivo	METHODS: To investigate the immunomodulatory effects, BAY 11-7082 (5-10 mg/kg) was injected intraperitoneally into C57BL/6 mice, followed 1 h later by intravenous injection of poly U (50 µg/head) + in vivo-jetPEI. RESULTS: Treatment with BAY 11-7082 inhibits the IFN response in vivo by limiting pDC function when stimulated with TLR ligands. METHODS: To investigate the effects on psoriasiform dermatitis, BAY 11-7082 (20 mg/kg) was injected intraperitoneally into C57BL/6 and NLRP3 KO mice with IMQ-induced psoriasiform lesions once daily for seven days. RESULTS: BAY 11-7082 blunted epidermal thickness, acanthosis and inflammatory infiltrates.BAY 11-7082 decreased the expression of pNF-κB, NLRP3, TNF-α, IL-6 and IL-1β, attenuated the phosphorylation of signal transducers and STAT3, and lowered IL-23 levels. Read more...
In Vitro	METHODS: Human colorectal cancer cells HT29 were treated with BAY 11-7082 (10-100 µM) for 1 h, followed by stimulation with TNF (50 ng/mL) for 3-10 min or Flag-TWEAK (200 ng/mL) for 8 h. The expression levels of target proteins were detected by Western Blot. RESULTS: Bay 11-7082 inhibited TWEAK-induced p100 processing and TNF-induced phosphorylation and degradation of IκBα. Both NFκB pathways were significantly blocked at concentrations of 30-100 µM of Bay 11-7082. METHODS: Macrophage RAW264.7 was treated with BAY 11-7082 (15 µM) and LPS (1 µg/mL) for 6 h, and TNF-α levels were measured by ELISA Assay. RESULTS: BAY 11-7082 blocked TNF-α production in LPS-treated RAW264.7 cells, which is an inflammatory response generated by activated NF-κB. Read more...
Cell Research	Cells are transfected with siRNA in 96-well microtiter plates and then cultured for 72 hours in complete NSCLC medium, treated with BAY 11-7082 for 12 hours. Cells are incubated with [3H]thymidine for 3 hours. The cells are collected on filters using an automatic cell harvester and radioactivity on the filters is measured by β-scintillation counting.(Only for Reference) Read more...

Storage & Handling

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Storage	store at low temperature,keep away from direct sunlight,store under nitrogen \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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ubiquitin, T-cell, phosphorylation, adhesion, Apoptosis, Autophagy, BAY 117082, BAY 11-7082, BAY 11-7821, BAY 11 7082, B-cell, cytokine, Deubiquitinase, DUBs, I kappa B kinase, leukaemic, IKK, IkB, IkB/IKK, E2-conjugating enzymes, Inhibitor, inhibit, IκBα phosphorylation, IκB, IκB kinase, inflammasome, lymphoma

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Compound Identifiers

PubChem CID

5353431 ↗

Key Properties

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No computed properties available.

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Protocol Information

Find More Protocols

J Guo, X Ma, L Wu, W Zhao, Y Zhang, C Hao, Y Yang, Z Yin, T Xu, Y Zhang, Y Guo, X Cao Inhibition of Nuclear factor kappa B ameliorates bone destruction and osteoclastogenesis in collagen-induced arthritis mice African Health Sciences, (2025)

PubMed: 41640567

BAY 11-7082 (orb1307179)

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Purity:	>98% (HPLC)
CAS Number:	1716-12-7
MW:	186.18
Formula:	C₁₀H₁₁NaO₂

Purity:	>98% (HPLC)
CAS Number:	1821-12-1
MW:	164.2
Formula:	C₁₀H₁₂O₂

Purity:	>98% (HPLC)
CAS Number:	19542-67-7
MW:	207.249
Formula:	C₁₀H₉NO₂S

BAY 11-7082

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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BAY 11-7082 (orb1307179)

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