Bazedoxifene

SKU: orb3027356

Description

Bazedoxifene is a non-steroidal, orally active selective estrogen receptor modulator that exhibits activity against ERα and ERβ with IC50 values of 26 nM and 99 nM, respectively. Bazedoxifene also inhibits IL-6/GP130 protein interactions. Bazedoxifene is utilized in research on postmenopausal osteoporosis and pancreatic cancer, serving as a dual-purpose compound for hormonal and cytokine pathway investigations.

Research Area

Immunology & Inflammation, Metabolism Research

Images & Validation

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Key Properties

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CAS Number	198481-32-2
MW	470.61
Purity	98.79%
Formula	C₃₀H₃₄N₂O₃
SMILES	OC=1C=CC(=CC1)C2=C(C3=CC(O)=CC=C3N2CC4=CC=C(OCCN5CCCCCC5)C=C4)C
Target	Others,Estrogen/progestogen Receptor,IL Receptor,Estrogen Receptor/ERR
Solubility	DMSO:80 mg/mL (169.99 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (7.01 mM)

Bioactivity

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Target IC50	ERα:26 nM\|ERβ:99 nM
In Vivo	In the Capan-1 and HPAF-II pancreatic carcinoma xenograft models in mice, Bazedoxifene (5mg/kg/d, administered continuously for 18 days) significantly inhibited tumor growth and induced tumor cell apoptosis. The effect was more pronounced when used in combination with chemotherapeutic agents . Read more...
In Vitro	In PANC-1, AsPC-1, and HPAF-II pancreatic carcinoma cells, Bazedoxifene (5-20μM, 2 hours) can inhibit IL-6 and IL-11-induced STAT3 phosphorylation in a dose-dependent manner . Read more...

Storage & Handling

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Storage	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Bazedoxifene, TSE424, TSE-424

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Gene Symbol

Others,Estrogen/progestogen Receptor,IL Receptor,Estrogen Receptor/ERR

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Bazedoxifene (orb3027356)

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Purity:	>99.99% (May vary between batches)
CAS Number:	198481-33-3
MW:	530.67
Formula:	C₃₂H₃₈N₂O₅

CAS Number:	328933-67-1
MW:	822.85
Formula:	C₄₂H₅₀N₂O₁₅

CAS Number:	2955243-69-1
MW:	419.30
Formula:	C₂₁H₁₀F₅NO₃

Purity:	98.74%
CAS Number:	198480-56-7
MW:	507.06
Formula:	C₃₀H₃₅ClN₂O₃

CAS Number:	198481-32-2
MW:	470.6
Formula:	C₃₀H₃₄N₂O₃

Bazedoxifene

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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Bazedoxifene (orb3027356)

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