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BBO-8520

SKU: orb2566870

Description

BBO-8520 is a first-in-class dual-state KRASG12C inhibitor that covalently binds to the Switch-II pocket, blocking signaling in both ON and OFF conformations. It demonstrates potent activity in growth factor-stimulated in vitro assays and induces durable tumor regression in vivo, including in models resistant to OFF-state-only inhibitors. This makes it a valuable tool for oncology research targeting KRAS-driven cancers.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

Key Properties

CAS Number2893809-51-1
MW729.74
Purity97.88%
FormulaC35H33F6N7O2S
SMILESN#CC1=C(SC2=C(F)C=CC(=C12)C=3C(F)=C4N=C(N=C(C4=CC3C(F)(F)F)N5CC(N(C(=O)C=C)CC5C)C)OCC67N(CCC6)CC(F)C7)N
TargetKras,Ras
SolubilityDMSO:≥ 40 mg/mL;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (2.74 mM)

Bioactivity

In Vivo
BBO-8520 (10 mg/kg/d; po) inhibits pERK and KRAS G12C activation in the KrasG12C-p53 driven GEMM model, resulting in sustained tumor regression. Additionally, BBO-8520 demonstrates a strong dose- and time-dependent pharmacodynamic effect in KRASG12C mutant tumor-bearing mice, with pERK inhibition exceeding 80% .

Storage & Handling

Storagekeep away from direct sunlight,store under nitrogen,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

BBO8520

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  • BBO-8520 [orb3032929]

    0.98

    2893809-51-1

    729.74

    C35H33F6N7O2S

    5 mg
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Key Properties

No computed properties available.

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BBO-8520 (orb2566870)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 470.00
5 mg
$ 760.00
10 mg
$ 1,040.00
1 ml x 10 mM (in DMSO)
$ 1,190.00
25 mg
$ 1,630.00
50 mg
$ 2,470.00
DispatchUsually dispatched within 5-10 working days
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