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BC-DXI-843

SKU: orb1298911

Description

BC-DXI-843 is a small molecule inhibitor targeting the oncogenic splice variant AIMP2-DX2. It shows potential for developing novel lung cancer therapeutics, with research applications in both in vitro cell-based assays and in vivo xenograft models to study its anti-tumor effects.

Images & Validation

Key Properties

CAS Number2421117-98-6
MW546.66
Purity>99.99% (May vary between batches)
FormulaC28H26N4O4S2
SMILESCOc1ccc(cc1)-c1csc(NC(=O)[C@H](Cc2c[nH]c3ccccc23)NS(=O)(=O)c2ccc(C)cc2)n1
TargetOthers
SolubilityDMSO:245 mg/mL (448.18 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (9.15 mM)

Bioactivity

Target IC50
AIMP2-DX2:0.92 μM (IC50)|AIMP2:IC50 >100 μM
In Vivo
BC-DXI-843 demonstrated in vivo efficacy in a tumor xenograft mouse model (H460 cells) at a dosage of 50 mg/kg, suggesting it as a promising lead for development of novel therapeutics targeting AIMP2-DX2 in lung cancer.
In Vitro
Optimization of hit BC-DXI-04 (IC50 = 40.1 μM) provided new potent sulfonamide based AIMP2-DX2 inhibitors. Among these, BC-DXI-843 showed improved inhibition against AIMP2-DX2 (IC50 = 0.92 μM) with more than 100-fold selectivity over AIMP2 in a luciferase assay. Several binding assays indicated that this compound effectively induces cancer cell apoptosis by specifically interrupting the interaction between DX2 and HSP70, which leads to the degradation of DX2 via Siah1-mediated ubiquitination.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

A549, AIMP2-DX2, BC DXI 843, BC-DXI 843, BCDXI843, BC-DXI843, BC-DXI-843, cancer, Inhibitor, inhibit, lung

Similar Products

  • BC-DXI-843 [orb1220098]

    >98% (HPLC)

    2421117-98-6

    546.66

    C28H26N4O4S2

    100 mg, 1 g, 500 mg, 200 mg, 2 mg, 5 mg, 10 mg, 25 mg, 50 mg
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Key Properties

No computed properties available.

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Protocol Information

BC-DXI-843 (orb1298911)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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2 mg
$ 80.00
5 mg
$ 100.00
1 ml x 10 mM (in DMSO)
$ 120.00
10 mg
$ 140.00
25 mg
$ 220.00
50 mg
$ 300.00
100 mg
$ 430.00
200 mg
$ 590.00
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