Beclomethasone 17-propionate

SKU: orb1992940

Description

Beclomethasone 17-propionate (17-BMP) is the active glucocorticoid metabolite of beclomethasone dipropionate. With 13-fold greater GR affinity than BDP, it potently suppresses pro-inflammatory cytokines like CXCL8, TNF-α, and IL-6. This mechanism underpins its research applications in studying asthma and allergic rhinitis pathophysiology in both cellular and animal models.

Research Area

Metabolism Research

Images & Validation

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Key Properties

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CAS Number	5534-18-9
MW	464.98
Purity	98.06% (May vary between batches)
Formula	C₂₅H₃₃ClO₆
SMILES	O(C(CC)=O)[C@@]1(C(CO)=O)[C@]2(C)[C@@](C[C@@H]1C)([C@]3([C@](Cl)([C@@H](O)C2)[C@]4(C)C(CC3)=CC(=O)C=C4)[H])[H]
Target	Drug Metabolite,Glucocorticoid Receptor
Solubility	10% DMSO+90% Corn Oil:3.3 mg/mL (7.1 mM);DMSO:100 mg/mL (215.06 mM)

Bioactivity

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In Vitro	Beclomethasone 17-propionate has EC50 values of 0.05 nM, 0.01 nM, and 0.1 nM for IL-6, TNFα, and CXCL8, respectively.

Storage & Handling

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Storage	store at low temperature,keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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17-BMP, Beclomethasone, Beclomethasone 17 propionate, Beclomethasone 17propionate, Beclomethasone 17-propionate, Beclomethasone-17-monopropionate

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Compound Identifiers

PubChem CID

62965 ↗

Key Properties

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No computed properties available.

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