Bemnifosbuvir hemisulfate

SKU: orb1298178

Description

Bemnifosbuvir hemisulfate (AT-527) is a direct-acting antiviral nucleotide prodrug that potently inhibits hepatitis C virus (HCV) replication. It has demonstrated antiviral activity in both in vitro assays and in vivo clinical studies, making it a valuable tool for HCV research.

Research Area

Infectious Disease & Virology, Protein Biochemistry

Images & Validation

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Key Properties

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CAS Number	2241337-84-6
MW	1261.15
Purity	99.98% (May vary between batches)
Formula	C₄₈H₆₈F₂N₁₄O₁₈P₂S
SMILES	C[C@@H](C(OC(C)C)=O)N[P@@](OC1=CC=CC=C1)(OC[C@H]2O[C@@H](N3C=NC4=C(NC)N=C(N)N=C34)[C@](C)(F)[C@@H]2O)=O.C[C@@H](C(OC(C)C)=O)N[P@@](OC5=CC=CC=C5)(OC[C@H]6O[C@@H](N7C=NC8=C(NC)N=C(N)N=C78)[C@](C)(F)[C@@H]6O)=O.O=S(O)(O)=O
Target	SARS-CoV,HCV Protease
Solubility	DMSO:170 mg/mL (134.8 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (3.96 mM)

Bioactivity

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Target IC50	SARS-CoV-2:0.47μM(EC90)\|HCV:5-28nM
In Vivo	When given orally to rats and monkeys, bemnifosbuvir hemisulfate preferentially delivered high levels of AT-9010 in the liver in vivo.These favorable preclinical attributes support bemnifosbuvir hemisulfate may increase SVR rates. Read more...
In Vitro	The potent in vitro activity of AT-511, the free base of bemnifosbuvir hemisulfate, against several coronaviruses, including SARS-CoV-2. In normal human airway epithelial cells, the concentration of AT-511 required to inhibit replication of SARS-CoV-2 by 90% (EC90) was 0.47 μM, very similar to its EC90 against human coronavirus (HCoV)-229E, HCoV-OC43, and SARS-CoV in Huh-7 cells. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Bemnifosbuvir, Bemnifosbuvir hemisulfate, Bemnifosbuvir Hemisulfate, antiviral, AT 527, AT527, AT-527, HCVProtease, HCV, HCV Protease, Hepatitis C virus, guanosine, Inhibitor, inhibit, pangenotypic, nucleotide, phosphoramidate, SARS coronavirus, SARSCoV, SARS-CoV, SARS-CoV-2

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Compound Identifiers

PubChem CID

155926085 ↗

Key Properties

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No computed properties available.

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