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BI605906

SKU: orb1707556

Description

BI605906 is a selective IKKβ inhibitor that blocks TNF-α-induced IκB degradation and subsequent IL-6 production. This mechanism supports its application in studying NF-κB-driven inflammatory pathways, with research utility in both cellular models and animal studies of conditions like psoriasis.

Research Area

Immunology & Inflammation, Signal Transduction

Images & Validation

Key Properties

CAS Number960293-88-3
MW432.51
Purity97.14% (May vary between batches)
FormulaC17H22F2N4O3S2
SMILESCCC(F)(F)c1cc(nc2sc(C(N)=O)c(N)c12)N1CCC(CC1)S(C)(=O)=O
TargetIL Receptor,IκB/IKK
SolubilityDMSO:40 mg/mL (92.48 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.31 mM)

Bioactivity

Target IC50
ATP (0.1 mM):|IKKβ:380 nM|ATP:0.1 mM|IKKβ:380 nM
In Vitro
BI605906, as a novel IKKβ inhibitor, inhibits TNFα-induced degradation of the NF-κB negative regulator IκB in primary mouse hepatocytes treated with metformin for 3 hours. Additionally, it regulates AMPK and MTOR signaling in a dose-dependent manner.

Storage & Handling

Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

BI605906, BI-605906, BI 605906, at 0.1 mM ATP, IKK, IkB/IKK, IkB, IκB, ILReceptor, IL-6, IKKβ, IL Receptor
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

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Protocol Information

BI605906 (orb1707556)

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% DMSO +
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% Tween 80 +
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Available Sizes

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1 mg
$ 70.00
5 mg
$ 120.00
1 ml x 10 mM (in DMSO)
$ 130.00
10 mg
$ 170.00
25 mg
$ 310.00
50 mg
$ 510.00
100 mg
$ 830.00
200 mg
$ 1,110.00
DispatchUsually dispatched within 5-10 working days
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