Biatractylolide

SKU: orb1680280

Description

Biatractylolide is a bioactive natural compound utilized in life science research. It serves as a valuable tool for in vitro and in vivo studies, particularly in pharmacological and phytochemical investigations exploring its biological activities.

Research Area

Cell Biology

Images & Validation

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Key Properties

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CAS Number	182426-37-5
MW	462.62
Formula	C₃₀H₃₈O₄
SMILES	CC1=C2[C@@](C[C@@]3(C)[C@](C2)(C(=C)CCC3)[H])(OC1=O)[C@]45C(C[C@]6([C@](C)(C4)CCCC6=C)[H])=C(C)C(=O)O5
Target	Apoptosis,Others

Bioactivity

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In Vivo	In SD rats with hippocampal Aβ₁₋₄₂-induced Alzheimer's disease model, oral administration of Biatractylolide (20 and 40 mg/kg/day, for 14 days) improved cognitive function (shortened escape latency in the Morris water maze), and reduced expression of p-Tau and cleaved caspase-3 in hippocampal tissue, suggesting neuroprotective and anti-Alzheimer’s potential. Read more...
In Vitro	In PC12 cells, Biatractylolide significantly attenuated Aβ₁₋₄₂-induced cytotoxicity (20, 40, and 80 μM, 24 h), increased cell viability, reduced ROS levels, and suppressed apoptosis-related protein expression (e.g., cleaved caspase-3 and Bax/Bcl-2 ratio), indicating antioxidant and anti-apoptotic properties. Read more...

Storage & Handling

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Storage	keep away from direct sunlight \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Biatractylolide, (+)-Biatractylolide

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Compound Identifiers

PubChem CID

11225032 ↗

Key Properties

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No computed properties available.

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