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Bicyclo-GABA

SKU: orb3210406

Description

Bicyclo-GABA is a selective competitive non-transportable inhibitor of the betaine/GABA transporter 1 (BGT1) with an IC50 of 590 nM. It exhibits low micromolar agonist activity at α1β2γ2GABAA receptors, with an EC50 of 5.1 μM. Bicyclo-GABA demonstrates activity that is 129 times higher for BGT1 than for GAT3. As a valuable tool compound, Bicyclo-GABA aids in elucidating its pharmacological role in both the central and peripheral nervous systems.

Images & Validation

Key Properties

CAS Number1615763-33-1
MW141.17
FormulaC7H11NO2
SMILESN[C@]12[C@]([C@@H](C(O)=O)CC1)(C2)[H]
TargetGABA Receptor

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information