Bimagrumab Antibody

SKU: orb2567411

Description

Bimagrumab (BYM338) is a human monoclonal antibody targeting the activin type II receptor. It is a valuable research tool for investigating metabolic disorders such as diabetes and obesity, with applications in both in vitro mechanistic studies and in vivo preclinical models.

Research Area

Stem Cell & Developmental Biology

Images & Validation

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Key Properties

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CAS Number	1356922-05-8
MW	142.78 kDa
Purity	98.00%
Target	TGF-beta/Smad,Others

Bioactivity

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Target IC50	ACVR2A:434 pM (Kd)\|ACVR2B:1.7 pM (Kd)
In Vivo	b>METHODS: Bimagrumab (Anti-ACVR2B Reference Antibody) (6, 20 mg/kg, subcutaneous injection) was used to treat mice and body weight was measured weekly to study its use in naive mice. RESULTS: Bimagrumab promoted weight gain and skeletal muscle hypertrophy in all examined mouse muscles, including slow, fast, and mixed muscles. Read more...
In Vitro	b>METHODS: Bimagrumab (Anti-ACVR2B Reference Antibody) (1 pM-1 μM) was used to treat HEK293 cells and its potency in inhibiting ActRII ligand signaling was evaluated in a Smad2/3 CAGA-luciferase reporter assay. RESULTS: Bimagrumab (Anti-ACVR2B Reference Antibody) showed similar dose-dependent inhibition of activin A-induced luciferase with an IC50 value of 343 ± 97 pM. Read more...

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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LY-3985863, LY3985863, LY 3985863, Anti-ACVR2B Reference Antibody, BYM 338, BYM338, BYM-338

Quality Guarantee

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Gene Symbol

TGF-beta/Smad,Others

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