Biotinylated Human IGFBP-4 Protein, ,Flag&His Tag (MALS verified)

SKU: orb2999598

Description

The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene.

Images & Validation

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Application Notes	This protein carries an Avi tag () and a Flag tag at the N-terminus followed by a polyhistidine tag at the C-terminus. The protein has a calculated MW of 30.7 kDa. The protein migrates as 33-35 kDa and 37 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Key Properties

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Expression System	HEK293
Target	IGFBP-4
Reactivity	Human
Tag	N-Avi & N-Flag & C-10×His
Molecular Weight	30.7 kDa
Expression Region	Asp 22 - Glu 258
Purity	90%
Conjugation	Biotin

Storage & Handling

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Storage	-20°C to -70°C for 12 months in lyophilized state;. -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower
Form/Appearance	Powder
Buffer/Preservatives	PBS, pH 7.4
Disclaimer	For research use only

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Quick Database Links

Gene Symbol

IGFBP-4

UniProt

P22692

UniProt Details

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No UniProt data available

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