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BIRT-377

SKU: orb1703683

Description

BIRT-377 is a potent, orally bioavailable negative allosteric inhibitor of the ICAM-1/LFA-1 interaction (Ki = 25.8 nM). It suppresses IL-2 production and is utilized in research models of inflammatory and autoimmune diseases, including in vitro adhesion assays and in vivo studies of immune cell recruitment.

Research Area

Immunology & Inflammation, Signal Transduction

Images & Validation

Key Properties

CAS Number213211-10-0
MW442.13
Purity99.93%
FormulaC18H15BrCl2N2O2
SMILESCN1C(=O)N(C(=O)[C@@]1(C)Cc1ccc(Br)cc1)c1cc(Cl)cc(Cl)c1
TargetIntegrin,Interleukin,IL Receptor
SolubilityDMSO:90 mg/mL (203.56 mM)

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

BIRT 377, BIRT377, BIRT-377, ICAM-1, IL Receptor, IL-2, ILReceptor, LFA-1
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Key Properties

No computed properties available.

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Protocol Information

BIRT-377 (orb1703683)

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Available Sizes

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1 mg
$ 90.00
5 mg
$ 170.00
10 mg
$ 240.00
25 mg
$ 500.00
50 mg
$ 720.00
100 mg
$ 1,000.00
500 mg
$ 1,960.00
DispatchUsually dispatched within 3-5 working days
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