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β-Bisabolene

SKU: orb1690495

Description

β-Bisabolene is a cytotoxic sesquiterpene that induces apoptosis in breast cancer cell lines such as MCF-10A, MDA-MB-231, and BT474. It is a compound of interest for in vitro cancer research, particularly in studies investigating natural product-based chemotherapeutic agents.

Research Area

Cell Biology

Images & Validation

Key Properties

CAS Number495-61-4
MW204.35
FormulaC15H24
SMILESC(CCC=C(C)C)(=C)[C@H]1CCC(C)=CC1
TargetApoptosis
Solubility10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (16.15 mM);DMSO:80 mg/mL (391.49 mM)

Bioactivity

In Vivo
In vivo experiments demonstrated that β-Bisabolene effectively inhibited the growth of transplanted 4T1 mammary tumors, reducing tumor volume by 37.5% at the experimental endpoint.
In Vitro
β-Bisabolene exhibits selective cytotoxicity: for murine cells, the half-maximal inhibitory concentration (IC₅₀) is >200 μg/ml for normal cells Eph4, 65.49 μg/ml for breast cancer cells MG1361, and 48.99 μg/ml for breast cancer cells 4T1; for Homo sapiens breast cancer cells, the IC₅₀ is 114.3 μg/ml for normal mammary epithelial cells MCF-10A, 66.91 μg/ml for breast cancer cells MCF-7, 98.39 μg/ml for breast cancer cells MDA-MB-231, 70.62 μg/ml for breast cancer cells SKBR3, and 74.3 μg/ml for breast cancer cells BT474.

Storage & Handling

StoragePure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

b-Bisabolene
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Key Properties

No computed properties available.

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β-Bisabolene (orb1690495)

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1 ml x 10 mM (in DMSO)
$ 70.00
25 mg
$ 80.00
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