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Ro 31-6045

SKU: orb1299504

Description

Bisindolylmaleimide V is an inactive analog of protein kinase C (PKC) inhibitors, serving as a negative control compound. It is widely used in biochemical and cellular research, including in vitro kinase assays and in vivo studies, to distinguish specific pharmacological effects from off-target activities.

Research Area

Epigenetics & Chromatin, Signal Transduction

Images & Validation

Key Properties

CAS Number113963-68-1
MW341.4
Purity>98%
FormulaC21H15N3O2
SMILESCN1C(=O)C(C2=CNC3=CC=CC=C23)=C(C1=O)C1=CNC2=CC=CC=C12
TargetKinase
SolubilitySoluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 9 mg/ml).

Bioactivity

Target IC50
S6K:8 μM
In Vitro
Bisindolylmaleimide V(BIM V) blocks the activation of mitogen-stimulated protein kinase p70s6k/p85s6k (S6K) in vivo with an IC50 value of 8 μM

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Bisindolylmaleimide V; BIM V
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Key Properties

No computed properties available.

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Protocol Information

Ro 31-6045 (orb1299504)

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1 mg
$ 170.00
5 mg
$ 360.00
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