Bisindolylmaleimide V

SKU: orb1299504

Description

Bisindolylmaleimide V is an inactive analog of protein kinase C (PKC) inhibitors, serving as a negative control compound. It is widely used in biochemical and cellular research, including in vitro kinase assays and in vivo studies, to distinguish specific pharmacological effects from off-target activities.

Research Area

Epigenetics & Chromatin, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	113963-68-1
MW	341.36
Purity	90.00% (May vary between batches)
Formula	C₂₁H₁₅N₃O₂
SMILES	CN1C(=O)C(C2=CNC3=CC=CC=C23)=C(C1=O)C1=CNC2=CC=CC=C12
Target	PKC,S6 Kinase
Solubility	DMSO:soluble

Bioactivity

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Target IC50	S6K:8 μM
In Vitro	Bisindolylmaleimide V(BIM V) blocks the activation of mitogen-stimulated protein kinase p70s6k/p85s6k (S6K) in vivo with an IC50 value of 8 μM

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Bisindolylmaleimide V, BIM V, inhibit, Inhibitor, PKC, Ribosomal S6 Kinase (RSK), S6Kinase, S6K, S6 Kinase

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Compound Identifiers

PubChem CID

2400 ↗

Key Properties

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No computed properties available.

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