BMS-345541 hydrochloride

SKU: orb1298849

Description

BMS-345541 hydrochloride is a potent and selective inhibitor of IκB kinase (IKK), exhibiting greater potency against IKK2 (IC50 = 0.3 µM) than IKK1 (IC50 = 4 µM). This small molecule is widely used in research to investigate NF-κB signaling pathways in cellular models and has been applied in animal studies to explore inflammation and oncology.

Research Area

Signal Transduction

Images & Validation

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Key Properties

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CAS Number	547757-23-3
MW	291.78
Purity	99.92%
Formula	C₁₄H₁₈ClN₅
SMILES	Cl.Cc1cnc2c(NCCN)nc3ccc(C)cc3n12
Target	IκB/IKK
Solubility	DMSO:18 mg/mL (61.69 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.85 mM)

Bioactivity

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Target IC50	IKKβ:0.3 μM\|IKKα:4 μM
In Vitro	BMS-345541 down-regulation of IKK activity results in mitochondria-mediated apoptosis of tumor cells because the programmed cell death machinery in melanoma cells is highly regulated by NF-kappaB signaling. Therefore, IKK may serve as a potential target for melanoma therapy. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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IkB/IKK, IkB, IKK, IKK1, IKK2, Inhibitor, I kappa B kinase, inhibit, IκB, IκB kinase, BMS345541, BMS-345541, BMS345541 hydrochloride, BMS345541 Hydrochloride, BMS-345541 Hydrochloride, BMS 345541, BMS 345541 Hydrochloride, BMS 345541 hydrochloride

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Compound Identifiers

PubChem CID

9926054 ↗

Key Properties

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No computed properties available.

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