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BOC-D-FMK

SKU: orb1309914

Description

Boc-D-FMK is a cell-permeable, irreversible pan-caspase inhibitor that blocks apoptosis, including that induced by TNF-α with an IC50 of 39 µM. It is widely used in vitro to study apoptotic pathways and has been applied in vivo to investigate models of neurodegenerative and ischemic diseases.

Research Area

Cell Biology, Protein Biochemistry

Images & Validation

Key Properties

CAS Number634911-80-1
MW263.26
Purity97.02%
FormulaC11H18FNO5
SMILESCOC(=O)CC(NC(=O)OC(C)(C)C)C(=O)CF
TargetCaspase,Apoptosis
SolubilityDMSO:125 mg/mL (474.82 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (15.19 mM)

Bioactivity

In Vivo
Boc-D-FMK-fmk significantly reduces apoptosis in hepatocytes of bile duct-ligated rats, potentially enhancing survival rates following endotoxin exposure . A single injection of Boc-D-FMK offers prolonged protection, exceeding 8 weeks, against root avulsion-induced death in motor neurons (MNs), enabling these treated MNs to regenerate axons into an implanted peripheral nerve (PN) graft and successfully reinnervate the target muscle .
In Vitro
Boc-D-fmk inhibits TNFα-stimulated reactive oxygen species (ROS) generation . Boc-D-fmk (50 μM) prevents genistein-induced apoptosis of p815 cells. The release of mitochondrial apoptotic factors is inhibited by Boc-D-fmk .

Storage & Handling

Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Caspase, BOC D FMK, BOCDFMK, BOC-D-FMK, Apoptosis, Inhibitor, inhibit

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Key Properties

No computed properties available.

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Protocol Information

BOC-D-FMK (orb1309914)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 mg
$ 90.00
5 mg
$ 170.00
1 ml x 10 mM (in DMSO)
$ 190.00
10 mg
$ 220.00
25 mg
$ 410.00
50 mg
$ 560.00
100 mg
$ 760.00
200 mg
$ 1,030.00
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