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Bofutrelvir

SKU: orb1693098

Description

MPro Inhibitor 11a

Research Area

Infectious Disease & Virology

Images & Validation

Key Properties

CAS Number2103278-86-8
MW452.55
Purity99.92%
FormulaC25H32N4O4
SMILESC(N[C@@H](CC1CCCCC1)C(N[C@@H](C[C@H]2C(=O)NCC2)C=O)=O)(=O)C3=CC=4C(N3)=CC=CC4
TargetSARS-CoV
SolubilityEthanol:30 mg/mL (66.29 mM);DMSO:80 mg/mL (176.78 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.29 mM);DMF:30 mg/mL (66.29 mM)

Bioactivity

Target IC50
Mpro:53 nM
In Vivo
In K18-hACE2 mice infected with the SARS-CoV-2 Delta variant, MPro Inhibitor 11a (100 and 200 mg/kg; intraperitoneal injection; administered once daily at 100 and 200 mg/kg on day 0 and twice daily on days 1, 2, and 3 for 4 consecutive days) demonstrated a dose-dependent efficacy against lung viral titers, effectively reducing lung viral loads.
In Vitro
MPro Inhibitor 11a (24 hours) exhibits in vitro inhibitory activity against SARS-CoV-2 and its variants when combined with remdesivir treatment.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

DC-402234, MPro Inhibitor 11a, FB2001, SARS-CoV-2 3CL, SARSCoV
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Key Properties

No computed properties available.

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Protocol Information

Bofutrelvir (orb1693098)

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% DMSO +
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% Tween 80 +
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1 mg
$ 240.00
5 mg
$ 620.00
10 mg
$ 860.00
25 mg
$ 1,230.00
50 mg
$ 1,670.00
100 mg
$ 2,220.00
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