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BOS-318

SKU: orb1297770

Description

BOS-318 is a potent and selective Furin inhibitor with an IC50 of 1.9 nM, featuring slow dissociation kinetics and cell permeability. It is a valuable research tool for studying proprotein convertase function in cellular models and investigating viral entry pathways, including SARS-CoV-2, in vitro.

Images & Validation

Key Properties

CAS Number2387633-15-8
MW571.5
Purity99.66%
FormulaC28H32Cl2N6O3
SMILESCN1CCN(CC1)c1ncc(Oc2cc(CN3CCC(CC(O)=O)CC3)cc(n2)-c2cc(Cl)cc(Cl)c2)cn1
TargetOthers
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.5 mM);DMSO:35.5 mg/mL (62.12 mM)

Bioactivity

Target IC50
endogenous proteases (U2OS cells):23.5 nM|Furin:1.9 nM
In Vitro
METHODS: PEA and CuFi-1 cells were treated with BOS-318 (0.03, 0.1, 0.3, 1 μM, 72 hours) and PEA and cell viability was monitored to investigate the protective effect of BOS-318 against the toxic effects of bacterial toxins activated by Furin protein. RESULTS The cell viability of CuFi-1 cells treated with PEA was approximately 2% of the control level. A single 0.3 μM dose of BOS-318 significantly increased the cell viability of PEA-treated cells to approximately 88% of the control level.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

inhibit, Inhibitor, neutrophil elastase, ENaC, Furin, BOS 318, BOS318, BOS-318
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

BOS-318 (orb1297770)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 mg
$ 90.00
5 mg
$ 140.00
1 ml x 10 mM (in DMSO)
$ 170.00
10 mg
$ 200.00
25 mg
$ 370.00
50 mg
$ 560.00
100 mg
$ 790.00
DispatchUsually dispatched within 3-5 working days
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