BRD6989

SKU: orb1308524

Description

BRD6989 is a synthetic analog of cortistatin A that acts as a selective CDK8/19 kinase inhibitor, demonstrating an IC50 of approximately 200 nM. This compound is a valuable research tool for studying CDK8-mediated transcriptional regulation and has been utilized in both in vitro and in vivo models to investigate immunomodulation and oncology pathways.

Research Area

Cell Biology, Immunology & Inflammation

Images & Validation

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Key Properties

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CAS Number	642008-81-9
MW	264.33
Purity	99.43% (May vary between batches)
Formula	C₁₆H₁₆N₄
SMILES	CC1CCc2nc(N)c(C#N)c(-c3cccnc3)c2C1
Target	CDK,IL Receptor,Interleukin
Solubility	DMSO:11 mg/mL (41.61 mM);10% DMSO+90% Corn Oil:1 mg/mL (3.78 mM)

Bioactivity

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Target IC50

CDK8:200 nM (IC50)|CDK19 (recombinant):>30 μM (IC50)|CDK8 (recombinant):0.5 μM (IC50)

In Vitro

Pretreatment of BMDCs with BRD6989 (0-100 μM; for 48 hours) increases IL-10 production (EC50: ~1 μM). BRD6989 (0.6, 1.7, 5, 15 μM) suppresses phosphorylation of the STAT1 transactivation domain at Ser727 in IFNγ-stimulated BMDCs. BRD6989 (5 μM; 24 hours) enhances IL-10 production in activated human and murine macrophages and dendritic cells. BRD6989 (5 μM; ~2 hours) suppresses induction of STAT1–STAT2 activity and NF-κB activation to a varying degree after stimulation of BMDMs.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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cortistatin-A, CDK19/CycC, CDK19, CDK8/CycC, CDK8, BRD6989, BRD-6989, BRD 6989, CDK, Cyclin dependent kinase, BMDCs, Inhibitor, inhibit, ILReceptor, inflammatory, Interleukin, Interleukin Related, IL Receptor, IL-10, recombinant CDK19, recombinant CDK8

Quality Guarantee

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Compound Identifiers

PubChem CID

3835861 ↗

Key Properties

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No computed properties available.

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BRD6989

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

Quality Guarantee

Compound Identifiers

Key Properties

Documents Download

Request a Document

Protocol Information

BRD6989 (orb1308524)

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