Brefeldin A 4-O-nicotinate

SKU: orb3028480

Description

Brefeldin A 4-O-nicotinate (CHNQD-01228) is a dual inhibitor of Arf1 and BMX proteins with an IC50 value of 0.22 μM for T24 cell proliferation. It also suppresses T24 cell migration and colony formation in a dose-dependent manner, induces G1 phase arrest, and triggers apoptosis. By targeting BMX proteins, it inhibits the AKT/p-AKT and STAT3/p-STAT3 signaling pathways, while also inhibiting Arf1 proteins to eliminate bladder cancer stem cells and activate antitumor immunity, thus exhibiting anticancer activity. Brefeldin A 4-O-nicotinate is applicable in research related to bladder cancer.

Research Area

Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	3035018-34-6
MW	385.453
Formula	C₂₂H₂₇NO₅
SMILES	O(C(=O)C=1C=CC=NC1)[C@H]/2[C@]3([C@@](C[C@H](O)C3)(/C=C/CCC[C@H](C)OC(=O)\C=C2)[H])[H]
Target	BTK,GTPase

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Gene Symbol

BTK,GTPase

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