Broussochalcone A

SKU: orb1744803

Description

Broussochalcone A is a natural small molecule with antioxidant and xanthine oxidase inhibitory activity (IC50 = 2.21 μM). It demonstrates pro-apoptotic effects in various cancer cell lines, including renal and pancreatic carcinoma, through mechanisms involving ROS modulation and inhibition of targets like FOXO3 and NR4A1.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	99217-68-2
MW	340.37
Purity	97.20%
Formula	C₂₀H₂₀O₅
SMILES	C(/C=C/C1=CC(O)=C(O)C=C1)(=O)C2=CC(CC=C(C)C)=C(O)C=C2O
Target	FOXO,ROS,Reactive Oxygen Species,Xanthine Oxidase,NR4A,Apoptosis
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (9.7 mM);DMSO:80 mg/mL (235.04 mM)

Bioactivity

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In Vitro

Methods: Broussochalcone A (1-30 μM) was incubated with DPPH (100 μM) at room temperature for 30 min, and the decrease in absorbance at 517 nm was measured. The DPPH scavenging activity of BCA was investigated. Results: The scavenging activity of Broussochalcone A was concentration-dependent. Methods: Cells were treated with Broussochalcone A (1-20 μM) for 30 min and then stimulated with LPS (1 mg/mL). After 24 h, nitrite levels in the culture medium were analyzed by Griess reaction. Its effect on nitrite production in LPS-activated RAW 264.7 macrophages was investigated. Results: Broussochalcone A inhibited nitrite production in a concentration-dependent manner, and its IC50 value was calculated to be 11.3±0.8 μM.

Storage & Handling

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Storage	keep away from moisture,store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Compound Identifiers

PubChem CID

6438825 ↗

Key Properties

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No computed properties available.

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