Broussochalcone A

SKU: orb1744803

Description

Broussochalcone A is a natural antioxidant and xanthine oxidase inhibitor (IC50 = 2.21 μM) that scavenges free radicals, inhibits iron-induced lipid peroxidation, and reduces nitric oxide synthesis in LPS-activated macrophages. Broussochalcone A induces apoptosis in human renal carcinoma cells by increasing ROS levels and activating the FOXO3 signaling pathway. Broussochalcone A is also a novel NR4A1 inhibitor that induces apoptosis in pancreatic cancer cells through NR4A1-dependent pathways.

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Key Properties

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CAS Number	99217-68-2
MW	340.37
Purity	97.20%
Formula	C₂₀H₂₀O₅
SMILES	C(/C=C/C1=CC(O)=C(O)C=C1)(=O)C2=CC(CC=C(C)C)=C(O)C=C2O
Target	Apoptosis,FOXO,Xanthine Oxidase,NR4A,Reactive Oxygen Species

Storage & Handling

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Storage	-20°C
Disclaimer	For research use only

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Apoptosis,FOXO,Xanthine Oxidase,NR4A,Reactive Oxygen Species

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