BU 224 hydrochloride

SKU: orb1306110

Description

BU 224 hydrochloride is a selective ligand for imidazoline I₂ binding sites. It exhibits antinociceptive and antidepressant-like effects in preclinical models, making it a useful research tool for studying pain, depression, and related neuropharmacology in both in vitro and in vivo experiments.

Research Area

Cell Biology, Neuroscience

Images & Validation

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Key Properties

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CAS Number	205437-64-5
MW	233.7
Purity	99.51%
Formula	C₁₂H₁₂ClN₃
SMILES	Cl.C1CN=C(N1)c1ccc2ccccc2n1
Target	Apoptosis,Imidazoline Receptor,TNF
Solubility	DMSO:3 mg/mL (12.84 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (4.28 mM)

Bioactivity

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In Vivo

BU 224 hydrochloride (5 mg/kg; i.p.) attenuated spatial and perirhinal cortex-dependent recognition memory deficits in 5XFAD mice. Fear-conditioning testing revealed that BU 224 hydrochloride also improved both associative learning and hippocampal- and amygdala-dependent memory in transgenic but not in WT mice. In the brain, BU 224 hydrochloride reduced levels of the microglial marker Iba1 and pro-inflammatory cytokines IL-1β and TNF-α and increased the expression of astrocytic marker GFAP in 5XFAD mice.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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5-HT, Alzheimer's disease, ACTH, anti-inflammatory, antidepressant, anti-apoptotic, Apoptosis, BU 224, BU 224 hydrochloride, BU 224 Hydrochloride, BU224, BU-224, BU224 Hydrochloride, BU-224 Hydrochloride, neuroprotective, Inhibitor, inhibit, ImidazolineReceptor, Imidazoline, Imidazoline Receptor, TNFR, TNF Receptor, Tumor Necrosis Factor Receptor

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Compound Identifiers

PubChem CID

11957470 ↗

Key Properties

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No computed properties available.

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