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Bufarenogin

SKU: orb1297437

Description

Bufarenogin is a bufadienolide compound isolated from the Cuban toad _Peltophryne fustiger_. This natural product exhibits anti-tumor activity and has been investigated in vitro for its cytotoxic effects against various cancer cell lines.

Research Area

Cell Biology, Signal Transduction

Images & Validation

Key Properties

CAS Number17008-65-0
MW416.51
Purity98.77%
FormulaC24H32O6
SMILESC[C@@]12[C@@](O)([C@]3([C@](C(=O)[C@H]1O)([C@]4(C)[C@](CC3)(C[C@@H](O)CC4)[H])[H])[H])CC[C@@H]2C=5C=CC(=O)OC5
TargetERK,Apoptosis,Bcl-2 Family,MEK,PI3K
SolubilityDMSO:50 mg/mL (120.05 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.8 mM)

Bioactivity

In Vitro
Bufarenogin caused cell death via apoptosis. Bufarenogin induced B-cell lymphoma 2-associated X protein (Bax)-dependent intrinsic apoptosis, as demonstrated by mitochondrial translocation of Bax and cytoplasm release of HCT116 wild-type cells and cytochrome C. Bufarenogin induced intrinsic apoptosis through the cooperation of Bax and adenine-nucleotide translocator and inhibited the metastasis and growth of orthotopical CRC cells.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

PI3K, MEK, ERK, Bufarenogin, 3beta,12beta,14-Trihydroxy-11-oxo-5beta-bufa-20,22-dienolide

Similar Products

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    99.34%

    17008-69-4

    416.51

    C24H32O6

    1 mg, 10 mg, 25 mg, 1 ml x 10 mM (in DMSO), 5 mg
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Key Properties

No computed properties available.

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Bufarenogin (orb1297437)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 120.00
5 mg
$ 230.00
1 ml x 10 mM (in DMSO)
$ 260.00
10 mg
$ 340.00
25 mg
$ 560.00
50 mg
$ 790.00
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