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Butoconazole

SKU: orb1220127

Description

Butoconazole is an imidazole antifungal agentButoconazole is particularly effective against in vivo Candida albicans infections (mice), maintaining good activity down to 0.25% formulation strength and showing unusually low reinfection rates after treatment is ended.Butoconazole 1-BSR is an effective and safe alternative to longer-term therapy with miconazole nitrate (seven days) for vulvovaginal candidiasis.

Images & Validation

Key Properties

CAS Number64872-76-0
MW411.76
Purity>98% (HPLC)
FormulaC19H17Cl3N2S
SMILESClc1ccc(CCC(Cn2ccnc2)Sc2c(Cl)cccc2Cl)cc1
TargetAntifungal
SolubilityDMSO:77 mg/ml(187 mM)

Bioactivity

In Vitro
Imidazoles generally inhibit the conversion of lanosterol to ergosterol, resulting in a change in fungal cell membrane lipid composition. This structural change alters cell permeability and, ultimately, results in the osmotic disruption or growth inhibition of the fungal cell.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole

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Butoconazole (orb1220127)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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