Butyl chlorogenate

SKU: orb1737441

Description

Butylchlorogenate is a natural small molecule compound extracted from the plants Lonicera japonica and Urceola rosea. It is utilized in research for its potential biological activities, with studies investigating its effects in both in vitro assays and in vivo models.

Research Area

Protein Biochemistry

Images & Validation

−

Key Properties

−

CAS Number	132741-56-1
MW	410.42
Purity	99.62% (May vary between batches)
Formula	C₂₀H₂₆O₉
SMILES	C(OCCCC)(=O)[C@@]1(O)C[C@@H](OC(/C=C/C2=CC(O)=C(O)C=C2)=O)[C@H](O)[C@H](O)C1
Target	Tyrosinase,Others
Solubility	DMSO:4.11 mg/mL (10.01 mM)

Bioactivity

−

In Vitro

Butyl chlorogenate were evaluated for their inhibitory activity against melanogenesis in α-MSH-stimulated B16 melanoma cells, five caffeoylquinic acids, i.e. Butyl chlorogenate exhibited inhibitory activities with 33-62% reduction of melanin content at 100 μM concentration with no or almost no toxicity to the cells (89-114% of cell viability at 100 μM). Western blot analysis showed that Butyl chlorogenate reduced the protein levels of microphtalmia-associated transcription factor (MITF), tyrosinase, tyrosine-related protein 1 (TRP-1), and TRP-2 mostly in a concentration-dependent manner, suggesting that this compound inhibits melanogenesis on α-MSH-stimulated B16 melanoma cells by, at least in part, inhibiting the expression of MITF, followed by decreasing the expression of tyrosinase, TRP-1, and TRP-2.

Storage & Handling

−

Storage	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Compound Identifiers

PubChem CID

12135130 ↗

Key Properties

−

No computed properties available.

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols