C 87

SKU: orb1308508

Description

C 87 is a small molecule that directly inhibits TNF-α by binding to it, blocking TNF-α-induced cytotoxicity (IC50 = 8.73 μM) and downstream signaling. It is a useful research tool for studying TNF-α-mediated inflammatory and autoimmune pathways in both cellular and animal models.

Research Area

Cell Biology

Images & Validation

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Key Properties

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CAS Number	332420-90-3
MW	502.93
Purity	≥98%
Formula	C₂₄H₁₅ClN₆O₃S
SMILES	[O-][N+](=O)c1cc(N\N=C2\C(=O)N(N=C2c2ccccc2)c2nc(cs2)-c2ccccc2)ccc1Cl
Target	TNF
Solubility	DMSO:5.06 mg/mL (10.06 mM)

Bioactivity

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Target IC50	TNF-α induced cytotoxicity:8.73 μM
In Vivo	In mice, the level of alanine transaminase and aspartate transaminase is consistently reduced. C 87 markedly reduces injuries to the liver and improves animal survival. C 87 injection delays the incidence of death and increases the survival rate by two fo Read more...
In Vitro	C 87 reduces the activity of c-Jun N-terminal kinase (JNK) in L929 cells. C 87 prevents the degradation of IκBα in cells treated with TNF-α and potently blocks multiple signaling transduction pathways and downstream target gene activation triggered by TNF-α. C 87 exhibits good solubility and consistent dose-dependent functions in vitro. C 87 completely blocks the TNFα-induced activation of caspase-3 and caspase-8. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Inhibitor, inhibit, C 87, C87, C-87, TNF Receptor, TNFR, TNFα-induced cytotoxicity, TNF-α, Tumor Necrosis Factor Receptor

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Compound Identifiers

PubChem CID

4016403 ↗

Key Properties

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No computed properties available.

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C 87 (orb1308508)

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Purity:	≥95%
MW:	3020.33

Purity:	> 95%
MW:	3020.33
Source:	Synthetic

Purity:	> 95%
MW:	2515.8
Source:	Synthetic

Purity:	≥95%
MW:	2515.8

Purity:	≥95%
MW:	5243.17

C 87

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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C 87 (orb1308508)

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