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Candoxatril

SKU: orb1710162

Description

Candoxatril (UK-79300) is an orally bioavailable neutral endopeptidase (NEP) inhibitor. It has been studied in chronic heart failure research, demonstrating improved exercise capacity in patients concurrently treated with ACE inhibitors, as supported by clinical trial literature.

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number123122-55-4
MW515.64
Purity98.90%
FormulaC29H41NO7
SMILESC([C@H](C(OC=1C=C2C(=CC1)CCC2)=O)COCCOC)C3(C(N[C@H]4CC[C@@H](C(O)=O)CC4)=O)CCCC3
TargetNeprilysin

Bioactivity

In Vivo
NEP inhibitors do not significantly affect body weight, food and water intake, mean blood pressure, or creatinine levels; however, they increase cGMP levels in urine and exhibit anti-inflammatory effects on hematopoiesis. Additionally, a-SMA deposition in the kidney cortex is inversely correlated with cGMP elevation .

Storage & Handling

Storagestore at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

NEP, neutral endopeptidase (NEP), Candoxatril, UK 79300, UK79300, UK-79300
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

Candoxatril (orb1710162)

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% DMSO +
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% Tween 80 +
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Available Sizes

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1 mg
$ 340.00
5 mg
$ 760.00
10 mg
$ 1,030.00
25 mg
$ 1,530.00
50 mg
$ 2,020.00
100 mg
$ 2,790.00
DispatchUsually dispatched within 6-8 weeks
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