Capromorelin Tartrate

SKU: orb1296264

Description

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	193273-69-7
MW	655.7
Purity	98.98%
Formula	C₃₂H₄₁N₅O₁₀
SMILES	O[C@H]([C@@H](O)C(O)=O)C(O)=O.CN1N=C2CCN(C[C@@]2(Cc2ccccc2)C1=O)C(=O)[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N
Target	GHSR
Solubility	DMSO:100 mg/mL (152.51 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (6.1 mM)

Bioactivity

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Target IC50	GHS-R1a (human):7 nM (Ki)
In Vivo	Capromorelin demonstrates enhanced intestinal absorption in rodent models and exhibits superior pharmacokinetic properties, including high bioavailabilities in rats ( = 5%) and dogs ( = 4%). It stimulates GH release in anesthetized rats with an ED50 of 0.05 mg/kg iv. In dogs, capromorelin (30 mg/mL) significantly increases food consumption and results in a weight gain of 0.52 kg compared to the placebo group. Read more...
In Vitro	Capromorelin stimulates GH release in rat pituitary cell cultures (EC50: 3 nM).
Animal Research	The study tested capromorelin flavored oral solution with 30 mg mL of capromorelin compared to a matched placebo flavored oral solution treatment (which contains al the ingredients o the formulation without capromorelin) administered for 4 days. Dogs are andomized into two groups, with Group 1 receiving placebo (0.1 L/kg) and Group 2 receiving 3.0 mg/kg. Both groups are treated once a day at approximately 9 AM Each day the first day of dosing is considered Day 0 the placebo and test drug are administered by a syringe placed in the corner o the mouth the Day 0 weight is used for dose calculations. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Disclaimer	For research use only

Alternative Names

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Inhibitor, inhibit, hGHS-R1a, Growth hormone secretagogue receptor, GHS-R, GHSR, CP 424391-18, Capromorelin, Capromorelin Tartrate

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Compound Identifiers

PubChem CID

9852610 ↗

Key Properties

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No computed properties available.

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