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Carpaine

SKU: orb1710151

Description

Carpaine is a natural alkaloid with antimalarial activity, showing an IC50 of ~4µM against P. falciparum in vitro. It also exhibits cardioprotective and anti-inflammatory properties in research models by modulating FAK, ERK1/2, and AKT signaling pathways and reducing oxidative stress.

Research Area

Cardiovascular Research, Immunology & Inflammation, Infectious Disease & Virology, Signal Transduction

Images & Validation

Key Properties

CAS Number3463-92-1
MW478.71
Purity99.39% (May vary between batches)
FormulaC28H50N2O4
SMILESC[C@H]1[C@@]2(CC[C@](N1)(CCCCCCCC(=O)O[C@@]3([C@H](C)N[C@](CCCCCCCC(=O)O2)(CC3)[H])[H])[H])[H]
TargetFAK,ERK,Parasite,Akt,ROS

Bioactivity

In Vivo
Circulatory effects of Carpaine were studied in Wistar male rats weighing 314 +/- 13 g, under pentabarbital (30 mg/kg) anesthesia. Increasing dosages of Carpaine from 0.5 mg/kg to 2.0 mg/kg resulted in progressive decrease in systolic, diastolic, and mean arterial blood pressure.

Storage & Handling

Storagekeep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Carpaine

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Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Carpaine (orb1710151)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO +
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% Tween 80 +
%

Available Sizes

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1 mg
$ 230.00
5 mg
$ 500.00
10 mg
$ 710.00
25 mg
$ 1,090.00
50 mg
$ 1,460.00
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