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CB2 receptor agonist 2

SKU: orb1306124

Description

CB2 receptor agonist 2 (ZINC72105556) is a potent and selective CB2 receptor agonist with a Ki of 8.5 nM. This high-affinity ligand is a valuable research tool for studying CB2-mediated pathways in vitro and in vivo within immunology and neuroinflammation research.

Research Area

Immunology & Inflammation; Pharmacology & Drug Discovery, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number1314230-75-5
MW488.62
Purity99.75% (May vary between batches)
FormulaC30H36N2O4
SMILESN(C(=O)C=1C(=O)C=2C(N(CCCCC)C1)=C(OC)C=C(C2)C3=CC=CO3)C45CC6CC(C4)CC(C5)C6
TargetCannabinoid Receptor
SolubilityDMSO:3 mg/mL (6.14 mM)

Bioactivity

Target IC50
CB2:8.5 nM (Ki)
In Vivo
CB2 receptor agonist 2 (compound 4g) (1 and 3 mg/kg; 1 hour) is highly potent, showing maximal effect at 1 mg/kg, with antihyperalgesic effects that are effective in the first phase of the nocifensive response and are strongly reduced by AM630, a CB2-selective antagonist/inverse agonist .
In Vitro
CB2 receptor agonist 2 (compound 4g) (1 μM, 72 hours) exhibits minimal to no cytotoxicity in Hep-G2 cells.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

CB2R, CB2 receptor agonist 2, CannabinoidReceptor, Cannabinoid Receptor, 4-Quinolone-3-Carboxamide Furan CB2 Agonist, ZINC 72105556, ZINC72105556, ZINC-72105556

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Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

1 mg
$ 160.00
2 mg
$ 220.00
5 mg
$ 330.00
10 mg
$ 460.00
25 mg
$ 690.00
50 mg
$ 910.00
100 mg
$ 1,210.00
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