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Cbl-b-IN-29

SKU: orb3173977

Description

Cbl-b-IN-29 is an orally active inhibitor of CBL-B. It effectively binds to the active site of CBL-B, thereby inhibiting the function of the immune E3 ubiquitin ligase. Cbl-b-IN-29 can induce the release of IL-2 from Jurkat cells with an EC50 of 159 nM. This compound exhibits significant antitumor efficacy in vivo, showing good tolerance with no adverse effects observed. Cbl-b-IN-29 is applicable in cancer immunotherapy and related studies involving colon cancer and tumor immunotherapy combinations.

Images & Validation

Key Properties

CAS Number3070411-10-5
MW499.63
FormulaC30H34FN5O
SMILESCN1C([C@@]2(C[C@H](C)C2)C3=CC(=CC=C3)C4=CC=5C(NC4=O)=C([C@H](NC6CCCC6)C)C=CC5F)=NN=C1
TargetInterleukin,E1/E2/E3 Enzyme

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Cbl-b-IN-29 (orb3173977)

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