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CC-92480

SKU: orb1219740

Description

CC-92480 is a cereblon E3 ubiquitin ligase modulating drug (CELMoD) with potent antimyeloma activity.CC-92480-induced loss of Aiolos and Ikaros in cultures of PBMCs resulted in the activation of T cells and increased production of IL-2 and IFN-γ. It exerts single-agent induction of apoptosis and exhibits remarkable synergy with NSC 34521. CC-92480 is effective in CC-4047, CC-5013, and CC-220-resistant cell lines.

Images & Validation

Key Properties

CAS Number2259648-80-9
MW567.61
Purity>98% (HPLC)
FormulaC32H30FN5O4
SMILESFc1cc(ccc1N1CCN(Cc2ccc(COc3cccc4C(=O)N(Cc34)[C@H]3CCC(=O)NC3=O)cc2)CC1)C#N
TargetE1
SolubilityDMSO:5 mg/mL (8.81 mM; ultrasonic and warming and heat to 60°C)

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Protocol Information

CC-92480 (orb1219740)

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Available Sizes

Select a size below

5 mg
$ 400.00
10 mg
$ 620.00
25 mg
$ 990.00
50 mg
$ 1,380.00
100 mg
$ 1,850.00
500 mg
$ 3,670.00