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CC-99677

SKU: orb1691401

Description

CC-99677 (Gamcemetinib) is a covalent, selective MK2 inhibitor developed for autoimmune disease research. It exhibits potent biochemical (IC50=156.3 nM) and cellular (EC50=89 nM in THP-1 cells) activity by blocking HSP27 phosphorylation via an SNAr mechanism. Its profile supports investigation into inflammatory pathways in both in vitro and in vivo models.

Research Area

Metabolism Research, Signal Transduction

Images & Validation

Key Properties

CAS Number1887069-10-4
MW469.94
Purity99.87%
FormulaC22H20ClN5O3S
SMILESCCOCc1cnc(Cl)nc1Oc1ccc2c3c4NC[C@@H](C)NC(=O)c4sc3ccc2n1
TargetMAPK,HSP
SolubilityDMSO:14.1 mg/mL (30 mM)

Bioactivity

In Vitro
CC-99677 is a potent, covalent, and irreversible inhibitor of the mitogen-activated protein (MAP) kinase-activated protein kinase-2 (MK2) pathway in both biochemical (IC50 =156.3 nM) and cell based assays ( EC50 =89 nM).

Storage & Handling

Storagestore at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Gamcemetinib, HSP, MAPKAPK2 (MK2), CC 99677, CC99677, CC-99677
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Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

CC-99677 (orb1691401)

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1 mg
$ 170.00
5 mg
$ 310.00
10 mg
$ 500.00
25 mg
$ 840.00
50 mg
$ 1,110.00
100 mg
$ 1,530.00
DispatchUsually dispatched within 5-10 working days
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