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CDK8-IN-13

SKU: orb1737465

Description

CDK8-IN-13 is a potent, selective, and orally bioavailable CDK8 inhibitor (IC50 = 51.9 nM). It induces apoptosis, suppresses p-STAT1 S727 and p-STAT5 S726, and demonstrates anti-tumor activity in research models, supporting its use in oncology and signal transduction studies.

Research Area

Cell Biology

Images & Validation

Key Properties

CAS Number918523-75-8
MW237.26
Purity99.28% (May vary between batches)
FormulaC14H11N3O
SMILESC(N)(=O)C=1C=C(C=2C=C3C(=NC2)NC=C3)C=CC1
TargetApoptosis,CDK
SolubilityDMSO:112.5 mg/mL (474.16 mM)

Bioactivity

Target IC50
CDK8:51.9 nM
In Vivo
CDK8-IN-13 (40, 80 mg/kg ; orally ; for 15 days) inhibits tumor growth in a dose-dependent manner in mice.
In Vitro
CDK8-IN-13 (compound 43 ; 1, 2.5, 5, 10 µM ; 12 h) decreased p-STAT1 S727 and p-STAT5 S726 expression in HCT-116 cells in a dose-dependent manner. CDK8-IN-13 (0, 1, 5, 10 µM ; 48 h) induced apoptosis in a dose-dependent manner.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

CDK8, CDK8IN13, CDK8-IN-13, Apoptosis
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Key Properties

No computed properties available.

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CDK8-IN-13 (orb1737465)

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Available Sizes

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1 mg
$ 80.00
1 ml x 10 mM (in DMSO)
$ 120.00
5 mg
$ 120.00
10 mg
$ 140.00
25 mg
$ 230.00
50 mg
$ 340.00
100 mg
$ 480.00
DispatchUsually dispatched within 3-5 working days
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