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Cearoin

SKU: orb1682980

Description

Cearoin is a natural compound that exhibits anticancer activity by inducing reactive oxygen species (ROS) generation, leading to autophagy, ERK activation, and apoptosis in SH-SY5Y neuroblastoma cells. It serves as a useful research tool for studying cell death mechanisms and signaling pathways in cancer research, both in vitro and in vivo.

Research Area

Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Metabolism Research, Molecular Biology, Protein Biochemistry, Signal Transduction

Images & Validation

Key Properties

CAS Number52811-37-7
MW244.24
Purity99.17% (May vary between batches)
FormulaC14H12O4
SMILESO=C(C=1C=CC=CC1)C=2C=C(O)C(OC)=CC2O
TargetAutophagy,PARP,ROS,Reactive Oxygen Species,Bcl-2 Family,ERK,Apoptosis,Caspase
SolubilityDMSO:40 mg/mL (163.77 mM)

Bioactivity

In Vitro
In human neuroblastoma SH-SY5Y cells, Cearoin (10-80 μM) significantly decreased cell viability in a dose-dependent manner and similarly stimulated phosphorylation of ERK and formation of LC3B-II in a dose-dependent way .

Storage & Handling

Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Cearoin, Caspase, 2,5-Dihydroxy-4-methoxybenzophenone, Bcl-2, IκB, NF-kB, NFkB, NFκB, NF-κB, NO, PARP, IKK, IkB/IKK, IkB, ERK, TNF-α, ROS
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

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Protocol Information

Cearoin (orb1682980)

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Available Sizes

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1 mg
$ 240.00
5 mg
$ 560.00
10 mg
$ 780.00
25 mg
$ 1,130.00
50 mg
$ 1,530.00
DispatchUsually dispatched within 5-10 working days
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