Cergutuzumab amunaleukin Antibody

SKU: orb1980500

Description

Cergutuzumab amunaleukin (CEA-IL2v) is an immunocytokine designed to target carcinoembryonic antigen (CEA)-expressing tumors. Its engineered IL-2 variant promotes immune cell activation and is investigated in preclinical in vitro and in vivo studies for solid cancer immunotherapy.

Research Area

Immunology & Inflammation

Images & Validation

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Key Properties

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CAS Number	1509916-03-3
MW	162.05 kDa
Purity	98% (SDS-PAGE); 99.7% (SEC-HPLC)
Target	Interleukin

Bioactivity

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In Vivo

Among the tumor-free mice treated with 0.5 and 2 mg/kg Cergutuzumab amunaleukin (i.v.; Once) the strong amplification of CD8+ T and NK cells after treatment.

In Vitro

Cergutuzumab amunaleukin contains a single IL-2 variant (IL2V) part. The CD25 is abolished and blends to the high-end C-terminal. By removing the combination of CD25, Cergutuzumab amunaleukin can avoid priority activation of regulating T cells relative to immune effect cells. Cergutuzumab amunaleukin activated the NK cells and converted into a killing of CEA-positive colon cancer cell line LS180, accompanied by the increase in the release of granase B, IFNγ, and RANTES, and the upward increase of CD25 and CD69 NK cells.

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Interleukin Related, CEA-IL2v, RG 7813, RO 6895882

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Gene Symbol

Interleukin

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