Chamaejasmenin B

SKU: orb1682966

Description

Chamaejasmenin B is a bioactive small molecule isolated from Stellera chamaejasme L., studied for its anticancer properties. It inhibits cancer cell migration, invasion, and metastasis in vitro and in vivo, with research applications in breast cancer and other tumor models.

Images & Validation

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Key Properties

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CAS Number	89595-71-1
MW	570.54
Purity	98.01%
Formula	C₃₂H₂₆O₁₀
SMILES	O=C1[C@]([C@H](OC=2C1=C(O)C=C(O)C2)C3=CC=C(OC)C=C3)([C@]4([C@H](OC=5C(C4=O)=C(O)C=C(O)C5)C6=CC=C(OC)C=C6)[H])[H]
Target	Others

Bioactivity

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In Vitro

Chamaejasmenin B exerted potent anti-proliferative effects in the 8 human solid tumor cell lines (HepG2, SMMC-7721, A549, MG63, U2OS, KHOS, HCT-116, and HeLa) with the IC50 values ranging from 1.08 to 10.8 μmol/L)) values ranged from 3.07 to 15.97 μmol/L). In the most sensitive A549 and KHOS cells, the mechanisms underlying the antiproliferative effects were characterized. The two compounds induced prominent expression of the DNA damage marker γ-H2AX as well as apoptosis. Furthermore, treatment of the cells with the two compounds caused prominent G(0)/G(1) phase arrest.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Chamaejasmenin A, Chamaejasmenin B

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Compound Identifiers

PubChem CID

21676273 ↗

Key Properties

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No computed properties available.

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