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Chelidamic acid

SKU: orb1301410

Description

Chelidamic acid is a pyran-based heterocyclic organic compound that acts as a glutamate decarboxylase inhibitor with a Ki of 33 μM. It is utilized in neuroscience research to study the GABAergic system and enzyme kinetics in both in vitro and cellular assay models.

Research Area

Neuroscience

Images & Validation

Key Properties

CAS Number138-60-3
MW183.12
Purity98.11% (May vary between batches)
FormulaC7H5NO5
SMILESC(O)(=O)C=1NC(C(O)=O)=CC(=O)C1
TargetGluR,Others
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (5.46 mM);DMSO:60 mg/mL (327.65 mM)

Bioactivity

Target IC50
Glutamate decarboxylase (GAD):33 μM (Ki)
In Vitro
Chelidonic acid inhibited the glutamate-dependent formation of apoenzyme. Chelidonic acid itself did not promote formation of apoenzyme and did not react with free pyridoxal-P.Chelidamic acid is inhibitors of glutamate decarboxylase, with a Ki of 33 μM.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Chelidamic acid, Glutamate Transporters, Inhibitor, inhibit

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    138-60-3

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Key Properties

No computed properties available.

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Chelidamic acid (orb1301410)

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1 g
$ 70.00
1 ml x 10 mM (in DMSO)
$ 70.00
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