Cinanserin hydrochloride

SKU: orb1308451

Description

Cinanserin hydrochloride (SQ 10643) is a dual-function research compound, acting as a potent 5-HT2 receptor antagonist (Ki: 41 nM) and an inhibitor of the SARS-CoV 3C-like protease. It has been utilized in vitro to study serotonin signaling and coronavirus replication mechanisms.

Research Area

Infectious Disease & Virology, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	54-84-2
MW	376.94
Purity	99.32%
Formula	C₂₀H₂₅ClN₂OS
SMILES	Cl.CN(C)CCCSc1ccccc1NC(=O)C=Cc1ccccc1
Target	5-HT Receptor,Influenza Virus
Solubility	H2O:100 mg/mL (265.29 mM);DMSO:125 mg/mL (331.62 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (10.61 mM)

Bioactivity

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Target IC50	3CLpro:\|5-HT2 receptor:41 nM (ki)
In Vivo	Cinanserin (5 mg/kg; intravenous injection; 2 hours; male Wistar rats) treatment significantly reduces systemic burn edema to shamburn levels.
In Vitro	Cinanserin and Cinanserin hydrochloride inhibit the catalytic activity of SARS-CoV 3CLpro and HCoV-229E 3CLpro (IC50: 4.68 μM and 5.68 μM). Cinanserin/Cinanserin hydrochloride has a binding affinity to SARS-CoV 3CLpro, HCoV-229E 3CLpro, with the KD values of 49.4 μM/78.0 μM for SARS-associated coronavirus (SARS-CoV) 3CLpro. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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5-HT2, 5-HT2 Receptor, 5-HT Receptor, 5HT Receptor, 5-hydroxytryptamine Receptor, 5HTReceptor, 3C-like, 3C-like proteinase, burn, Cinanserin, Cinanserin hydrochloride, Cinanserin Hydrochloride, Influenza Virus, InfluenzaVirus, inhibit, edema, endothelial, leukocyte, Inhibitor, proteinase, replication, SQ 10643, SQ10643, SQ-10643, systemic, Serotonin Receptor, virus

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Compound Identifiers

PubChem CID

5912 ↗

Key Properties

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No computed properties available.

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