Cinpanemab Antibody

SKU: orb1980583

Description

Cinpanemab (BIIB054) is a human monoclonal antibody targeting the N-terminal region (residues 1-10) of alpha-synuclein. It is a research tool for investigating Parkinson's disease and related synucleinopathies, utilized in both in vitro assays and in vivo models to study disease mechanisms and therapeutic strategies.

Images & Validation

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Key Properties

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CAS Number	2094516-02-4
MW	150 kDa
Purity	> 95%
Target	Others

Bioactivity

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In Vivo	Cinpanemab (30 mg/kg; intraperitoneal injection) ameliorates Parkinson's disease (PD)-like phenotypes in a mouse model inoculated with α-syn PFFs.
In Vitro	Cinpanemab exhibits high selectivity for aggregated forms of α-syn, with at least an 800-fold higher apparent affinity for fibrillar recombinant α-syn compared to monomeric recombinant α-syn, and it shows a strong preference for human Parkinson's disease (PD) brain tissue. Read more...

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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BIIB054, BIIB-054, BIIB 054, Cinpanemab, α-synuclein

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