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Claturafenib

SKU: orb2695470

Description

Claturafenib (PF-07799933) is a brain-permeable, selective, all-mutant BRAF inhibitor with broad inhibitory effects on pERK levels in HT29 cells.Claturafenib has shown antitumor activity in preclinical studies in both BRAF V600- and non-V600-mutant cancers and can be used in combination with MEK inhibitors.

Research Area

Signal Transduction

Images & Validation

Key Properties

CAS Number2754408-94-9
MW490.31
Purity99.85%
FormulaC18H15Cl2F2N5O3S
SMILESO=C1C2=C(N=CN1C)C=CC(NC=3C(F)=CC=C(NS(=O)(=O)N4CC(F)C4)C3Cl)=C2Cl
TargetRaf
SolubilityDMSO:80 mg/mL (163.16 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.73 mM)

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
DisclaimerFor research use only

Alternative Names

ARRY440, ARRY-440, PF07799933, PF-07799933
Quality Guarantee

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Claturafenib (orb2695470)

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% DMSO +
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% Tween 80 +
%

Available Sizes

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1 mg
$ 110.00
5 mg
$ 200.00
1 ml x 10 mM (in DMSO)
$ 240.00
10 mg
$ 290.00
25 mg
$ 440.00
50 mg
$ 740.00
DispatchUsually dispatched within 5-10 working days
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