Clofoctol

SKU: orb1225160

Description

Clofoctol is a bacteriostatic antibiotic. It is used in the treatment of respiratory tract and ear, nose and throat infections caused by Gram-positive bacteria.

Images & Validation

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Key Properties

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CAS Number	37693-01-9
MW	365.35
Purity	>98% (HPLC)
Formula	C₂₁H₂₆Cl₂O
SMILES	CC(C)(C)CC(C)(C)C1=CC(CC2=C(Cl)C=C(Cl)C=C2)=C(O)C=C1
Target	Others
Solubility	DMSO: 10 mM

Bioactivity

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In Vivo

Animal model: Male athymic nude mice (BALB/c, nu/nu-NCr) aged 4–6 weeks, human prostate cancer xenograft model. Dosage: 175 mg/kg. Administration: Intraperitoneal injection, daily for 37 days. Result: Significantly inhibited PC3 tumour growth, tumour weight was also reduced by 60%. Animal model: K18-hACE2 transgenic C57BL/6J mice with SARS-CoV-2 infection. Dosage: 62.5 mg/kg. Administration: Intraperitoneal injection, 1h and 8h post-infection. Result: Induced body weight loss, reduced the viral load in the lungs. The expression of transcripts encoding IL-6, TNFα, IL12p40, IFNβ, IFNγ and the interferon-stimulated genes (ISG) Mx1, Ifi44 and ISG15 was markedly reduced. Animal model: 8–10 week-old female C57BL/6J mice. Dosage: 62.5 mg/kg. Administration: Intraperitoneal injection, once (Pharmacokinetics). Result: Reached concentrations up to 61 μM in the lungs and remained above this level for almost 4h as early as 30 min after injection.

In Vitro

Cell Viability Assay Cell line: Prostate cancer cell lines: LNCaP, DU145, PC3, LAPC4, CWR22Rv1 and C42B. Concentration: 0-100 μM. Incubation time: 72 h. Result: Inhibited cell growth with IC50 values ranging from 10 to 15 μM. Cell Viability Assay Cell line: PC3. Concentration: 0, 10 and 20 μM. Incubation time: 24 h. Result: Induced a G1 arrest. RT-PCR Cell line: PC3. Concentration: 0, 5, 10, 15, 20 and 30 μM. Incubation time: 24 h. Result: Increased the splicing of XBP-1 mRNA in PC3 cells in a dose-dependent manner. Dose-dependently decreased PstI digestion products from XBP-1 mRNA. Western blot analysis. Cell line: PC3. Concentration: 0, 5, 10, 15, 20, 25 and 30 μM. Incubation time: 0, 0.5, 1, 3, 6 and 9 h or 24 h (cell cycle) Result: Dose- and time-dependently increased the level of phosphorylated eIF2α, up-regulated CHOP expression, and increased the expression of BiP. Led to a dose-dependent decrease in the levels of cyclin A and cyclin D1.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Clofoctol (orb1225160)

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Purity:	99.87% (May vary between batches)
CAS Number:	37693-01-9
MW:	365.34
Formula:	C₂₁H₂₆Cl₂O

Clofoctol

Description

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Key Properties

Bioactivity

Storage & Handling

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