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Clovamide

SKU: orb1305246

Description

Trans-Clovamide is a natural caffeoyl conjugate from cocoa with potent antioxidant, neuroprotective (EC50s = 0.9-3.7 µM in vitro), and anti-inflammatory properties. Its research applications extend to studies on oxidative stress, neurodegeneration, and antimicrobial activity against pathogens like H. pylori and influenza A/H5N1.

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Signal Transduction

Images & Validation

Key Properties

CAS Number53755-02-5
MW359.33
Purity97.68% (May vary between batches)
FormulaC18H17NO7
SMILESOC(=O)[C@H](Cc1ccc(O)c(O)c1)NC(=O)\C=C\c1ccc(O)c(O)c1
TargetInfluenza Virus,ROS,Reactive Oxygen Species,Antibacterial,Apoptosis
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (11.13 mM);DMSO:150 mg/mL (417.44 mM)

Bioactivity

In Vitro
Clovamide protects neurons from injury in three in vitro models of neuronal death: oxidative stress, excitotoxicity and OGD/reoxygenation. In SH-SY5Y human neuroblastoma cells, Clovamide (10-100 μM) protects cell death significantly with an EC50 value of 3.6 μM. Clovamide inhibits growth of three pathogens of cacao in the genus Phytophthora, is a substrate for cacao polyphenol oxidase, and is a contributor to enzymatic browning. Clovamide inhibits proteinase and pectinase in vitro. Clovamide also enhances PPARγ expression.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

N-trans-Caffeoy-L-dopa, H5N1, Clovamide, Apoptosis, Bacterial, phenolic, ROS, trans-Clovamide

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

2 mg
$ 80.00
5 mg
$ 100.00
1 ml x 10 mM (in DMSO)
$ 110.00
10 mg
$ 130.00
25 mg
$ 180.00
50 mg
$ 290.00
100 mg
$ 470.00
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