Clozapine N-oxide dihydrochloride

SKU: orb1745121

Description

Clozapine N-oxide dihydrochloride is a blood-brain barrier permeable agonist for the chemogenetic DREADD receptors hM3Dq and hM4Di. It is a key research tool for targeted neuronal manipulation in studies of neural circuits, behavior, and diseases, applicable in both in vitro and in vivo experimental models.

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	2250025-93-3
MW	415.74
Purity	98.11% (May vary between batches)
Formula	C₁₈H₂₁Cl₃N₄O
SMILES	C[N+]1(CCN(C2=NC3=CC(Cl)=CC=C3NC4=C2C=CC=C4)CC1)[O-].Cl.Cl
Target	Dopamine Receptor,AChR,Drug Metabolite,Cholinesterase (ChE)
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:10 mg/mL (24.05 mM);H2O:50 mg/mL (120.27 mM);DMSO:200 mg/mL (481.07 mM)

Storage & Handling

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Storage	store under nitrogen,store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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AChE, Clozapine N-oxide, Clozapine N-oxide Dihydrochloride

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Compound Identifiers

PubChem CID

171360898 ↗

Key Properties

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No computed properties available.

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